"The Americans are trying to provoke the Saudis and certain countries in the region and pit them against the Islamic Republic but if they have wisdom, they should not be deceived by the United States," the Leader said on Monday.
"The Americans do not want to suffer the cost of confronting the Islamic Republic and the powerful nation of Iran themselves; they want to make some states in the region shoulder it," the Leader told a group of laborers and entrepreneurs in Tehran ahead of Labor Day.
"Some countries in the region should know that if they face the Islamic Republic of Iran, they will definitely be hit and defeated," Ayatollah Khamenei added.
His remarks came a day after US Secretary of State Mike Pompeo visited Saudi Arabia where he called for unity among the Persian Gulf countries, deeply divided over Qatar, in order to face Iran.